Many women hit midlife and feel something they cannot name. They are still doing the right things, eating well, exercising consistently, showing up for everyone, yet life suddenly feels harder and less familiar. gives language to this experience and explains why it is not a failure, but a shift happening beneath the surface.
This is not a motivation problem.
This is not a discipline issue.
And it is not “all in your head.”
In this hol+ conversation, Dr. Taz sits down with New York Times bestselling author and leading voice in women’s health Dr. Mindy Pelz, host of the hit podcast The Resetter Podcast, to explore the core message behind Age Like a Girl: menopause is not a decline, it is a biologically wired reinvention.
Instead of treating perimenopause and menopause as a crisis to manage, Dr. Mindy reframes the transition as a neurochemical and cognitive remodel designed to make women more focused, emotionally resilient, and aligned with who they truly are. She breaks down why modern life often clashes with this primal design, and why brain fog, mood shifts, and emotional intensity are not random symptoms, but signals that the brain is asking for a new way of living.
This episode explores why women can feel anxious, disconnected, or unlike themselves even when they are “doing everything right,” and how metabolism, stress chemistry, and neurotransmitters shape mood, clarity, and identity. Dr. Taz and Dr. Mindy discuss why many women initiate big life and relationship changes after 40, why community and connection become essential, and why reinvention is not a midlife crisis, but biology.
From perimenopause into postmenopause, this conversation reframes aging as an awakening. Not the end of youth, but the return of clarity, boundaries, and self-trust. If you have ever felt dismissed, confused, or afraid that something is wrong with you, this episode offers a validating and hopeful roadmap forward.
Dr. Taz and Dr. Mindy Pelz Discuss:
- The core message of Age Like a Girl and why it reframes menopause
- Why the female brain is biologically wired for reinvention after 40
- Brain fog and mood shifts as signals of a cognitive remodel
- How modern life clashes with primal biology
- Why women often make major life decisions in midlife
- The role of neurotransmitters in clarity, calm, and confidence
- Why community and deep connection matter more than ever
- How to reclaim vitality without another exhausting checklist
About Dr. Mindy Pelz
Dr. Mindy Pelz is a New York Times bestselling author, visionary educator, and trailblazer in the field of women’s health and hormone science. With over two decades of experience, she’s built a global movement to help women understand the power of their bodies at every stage of life. Her bestselling books, including Fast Like a Girl, The Menopause Reset, and Eat Like a Girl, have helped millions of women use fasting, nutrition, and lifestyle shifts to balance hormones, boost energy, and take back control of their health. Her newest release book, Age Like a Girl, redefines what it means to grow older as a woman. Rooted in the latest science and rich in personal story, the book challenges outdated narratives about menopause and aging offering instead a roadmap for awakening. Dr. Mindy shows women how to use the neurochemical shifts of midlife as a launchpad for purpose, leadership, and bold reinvention.
Dr. Mindy’s Resetter Podcast consistently ranks among Apple’s top U.S. science shows, with guests ranging from LeAnn Rimes and Rachel Hollis to Dr. Rangan Chatterjee. Her YouTube channel has surpassed 110 million views, and her teachings have reached hundreds of thousands through workshops, online programs, and live events.
Stay Connected with Dr. Mindy Pelz
- Instagram: dr.mindypelz
- Podcast: The Resetter Podcast
- Website: drmindypelz.com
Stay Connected with Dr. Taz
- Subscribe to the audio podcast: https://holplus.transistor.fm/subscribe
- Subscribe to the video podcast: https://www.youtube.com/@DrTazMD/podcasts
Follow Dr. Taz
- Dr. Taz Instagram: https://www.instagram.com/drtazmd
- hol+ Instagram: https://www.instagram.com/liveholplus
- Join the conversation on X: https://x.com/@drtazmd
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Host: Dr. Taz; Edited and Produced by Clip Growth; Producer: Pat Gostek
Chapters
00:00 Why women feel different after 40
01:45 “I’m doing everything right, why do I feel worse?”
04:10 This is not burnout or lack of discipline
06:20 What actually changes in the female brain in midlife
09:15 Why brain fog and irritability show up
12:10 The neurochemical shift behind feeling “done”
15:30 Why pushing harder stops working after 40
18:40 Stress chemistry and why effort backfires
22:00 Why women start rewriting their lives in midlife
25:10 Relationships, tolerance, and clearer boundaries
29:30 Modern life vs female biology
33:20 Why rest and connection become non-negotiable
37:10 Identity shifts and reclaiming your authentic self
41:00 Midlife as reinvention, not decline
45:30 What real alignment looks like after 40
49:00 A new way to approach aging and energy
53:30 Final thoughts and takeaway for women in midlife