If you’ve been on a gut-healing journey, chances are you’ve heard about L-Glutamine dosage for leaky gut. It’s one of the most talked-about supplements for restoring the gut lining—but figuring out how much to take (and when) can feel a little confusing.
Leaky gut can show up in so many sneaky ways—bloating, food sensitivities, fatigue, even skin flare-ups. L-glutamine is a gentle but powerful ally that helps your gut lining rebuild and stay strong.
The Truth About Leaky Gut (And Why It’s So Common)
If you’re always bloated, sensitive to foods you used to eat with no problem, or feeling generally inflamed for no clear reason, your gut lining could be struggling. This invisible layer of protection keeps what’s inside your digestive system safely inside—until it starts to break down.
When the gut barrier becomes more porous than it should be, we call it “leaky gut,” or intestinal permeability. Tight junctions that normally act like gatekeepers between cells start to loosen. That opens the door for bacteria, food particles, and toxins to slip through and enter the bloodstream—setting off inflammation throughout the body.
What Can Trigger a Leaky Gut?
Even if you’re eating “healthy,” certain everyday factors can quietly erode the integrity of your gut wall.
- Chronic stress
- Processed and inflammatory foods
- Excess alcohol
- Medications like NSAIDs or antibiotics
- Food sensitivities
- Gut infections like Candida or SIBO
What Does It Feel Like?
Leaky gut doesn’t always show up the way you’d expect. It’s more than just a “bad stomach day.” Because your gut lining is deeply connected to your immune system, brain, skin, and hormones, symptoms can show up far from the digestive tract—and often feel unrelated.
You might notice:
- Digestive discomfort: Think bloating after meals, unpredictable bowels, or that “heavy” feeling that lingers long after you eat.
- Food sensitivities that seem to be multiplying: You react to things you never used to—dairy, gluten, eggs, even “healthy” foods like nuts or avocados.
- Low energy or brain fog: You wake up tired, struggle to focus, and feel like you’re dragging your body through the day.
- Skin issues: Eczema, acne, or random rashes that flare without a clear cause—your skin and gut are in constant conversation.
- Mood shifts: Irritability, anxiety, or low mood often have gut-based roots, especially when inflammation is involved.
- Aches, joint pain, or stiffness: These can be signs of systemic inflammation triggered by leaky gut.
- Weakened immunity: If you catch every bug going around or take forever to recover, your gut might be part of the story.
If you feel like your system is on edge for no obvious reason, your gut could be quietly asking for support. Healing the barrier can bring noticeable relief—in digestion, yes, but also in energy, mood, skin, and how you feel in your body overall.
L-Glutamine for Leaky Gut: What It Does (and Why It Works)
L-Glutamine is the amino acid your gut lining counts on—literally. It’s the primary fuel for the cells that maintain your intestinal wall, known as enterocytes. When these cells have what they need, they can rebuild, reinforce, and calm inflammation that’s been simmering under the surface.
A Closer Look at Its Benefits
Here’s how L-Glutamine shows up for your gut, especially when it’s feeling fragile:
- Supports gut cell regeneration: It feeds and energizes enterocytes, which helps them heal microtears and rebuild tissue more efficiently.
- Restores barrier integrity: Encourages the repair of tight junctions—those microscopic gates that decide what gets in and what stays out.
- Calms inflammation: By nourishing the gut lining, L-Glutamine helps quiet local immune responses that can drive systemic symptoms.
It’s especially valuable for people dealing with bloating, food sensitivities, post-infection recovery, or long-term gut imbalance. If you’ve ever felt like your digestion is “off” more days than not, this amino acid is worth getting familiar with.
Additional Supportive Roles
Beyond barrier repair, L-Glutamine also helps stabilize blood sugar, reduces sugar cravings (a common gut-healing hurdle), and supports immune cells in the gut lining. This makes it a gentle yet powerful tool in many integrative protocols—especially when paired with other gut-healing nutrients like zinc carnosine, aloe vera, or deglycyrrhizinated licorice.
The Sweet Spot: L-Glutamine Dosage for Leaky Gut
If you’re wondering about L-Glutamine dosage for leaky gut, you’re not alone—it’s one of the most common questions in gut healing protocols. Too little may not deliver enough support, but the right range, taken consistently, can truly help your gut lining recover.
Most people do well somewhere between 5 and 15 grams per day, depending on symptom severity, body size, and overall inflammation. It’s not a magic number—but a therapeutic range you ease into based on how your body responds.
General Guidelines for Gut Repair
Start slow and build gradually. Here’s a breakdown to guide you:
- Mild symptoms: Start around 5 grams per day
- Moderate to severe symptoms: 10–15 grams per day, ideally under the guidance of a provider
- Timing: Take on an empty stomach, morning and/or evening
- Duration: Most protocols run 4 to 12 weeks, depending on how your gut responds
You might find that dividing the dose (like 5 g twice daily) feels gentler on your system and helps your body absorb more efficiently. Tuning in and adjusting is part of the process.
A Smarter Approach to Gut Formulas
Sometimes, L-Glutamine works best when it’s part of a blend designed to do more than one thing. You’re not just repairing the gut lining—you’re also calming inflammation, feeding beneficial microbes, and easing bloating.
That’s why we love EastWest® Belly Fix. It combines L-Glutamine with collagen (great for tissue repair), MCTs for fuel, and a smart digestive blend that supports balance across the whole gut ecosystem. It’s a great pick for anyone dealing with leaky gut symptoms and looking to rebalance their belly from the inside out. Shop it here.
Gentle, Rooted, Personalized: The hol+ Difference
At hol+, we don’t take a one-size-fits-all approach to gut health. Whether you’re dealing with stubborn bloating, food sensitivities, fatigue, or the classic signs of leaky gut, we look at your whole system to find out what your body needs to truly heal. Supplements are only part of the equation—our board-certified team builds care plans that support every layer of your health.
Our Digestive Health Services
We create thoughtful, individualized care plans based on real data, your unique story, and your body’s feedback.
- Nutrition and diet recommendations
We help you build a deeply nourishing, gut-supportive eating plan—low in inflammatory triggers, rich in fiber, polyphenols, and amino acids that strengthen the lining. - Gut healing therapies
Depending on your needs, we may use a combination of herbal antimicrobials (when dysbiosis is present), targeted probiotics, and nutrients like L-Glutamine, zinc carnosine, and soothing demulcents. - Stress reduction techniques
Our team supports your nervous system with acupuncture, guided breathwork, yoga-based movement, and calming adaptogens—because a calm gut starts with a calm brain. - Lifestyle coaching
We help you create daily habits that support gut repair: mindful eating, consistent sleep, hydration rhythms, and joyful movement. - Medications when needed
If certain conditions (like IBD, GERD, or SIBO) call for it, we integrate medications or antimicrobials carefully into your plan—always balancing effectiveness with gentleness. - Ongoing, connected care
You won’t be left guessing. We check in, track your progress, adjust your protocol, and keep your healing journey clear and supported every step of the way.
We know gut issues can feel overwhelming, especially when they’ve been brushed off or misdiagnosed for years. Whether you’re just starting to explore what’s going on or you’ve tried everything and still feel off, we’re here to help you rebuild trust with your body.
Because Gut Health Is Whole-Body Health
Finding the right L-Glutamine dosage for leaky gut can make all the difference—but dosage is just one part of a bigger healing picture. When you combine the right nutrients with root-cause insight, personalized support, and gentle consistency, your body has the chance to truly repair. Healing your gut is about understanding what’s been stressing it in the first place—and building resilience from there.
Our team at hol+ is here to guide you with care that goes deeper than symptom relief. If you’re ready to get answers, feel supported, and finally feel like yourself again, let’s work together. Schedule your consultation today and start restoring your gut, naturally.
FAQs
What’s the best L-Glutamine dosage for leaky gut in mild cases?
A gentle starting dose is around 5 grams per day, usually on an empty stomach. You can split it into two smaller doses if that feels better for your body.
Can I take L-Glutamine long-term for leaky gut?
Short-term use (4–12 weeks) is typical, but some people benefit from longer support. It depends on your symptoms and how your gut responds. Always check in with a practitioner.
Should I take L-Glutamine powder or capsules?
Powder works well because you can easily adjust the dose and mix it into water or smoothies. Capsules are great for convenience—choose what fits your lifestyle.
What makes hol+’s approach to leaky gut different?
We go beyond supplements. We look at gut infections, stress, food sensitivities, and hormone imbalances to treat the why, not just the symptoms.
What if I’ve tried everything for my gut and still feel stuck?
That’s exactly why we’re here. We take time to dig deeper—so you’re not just handed another generic protocol, but real support that finally makes sense for your body. Schedule a consultation and let’s get started!